The primary aim of the present study was to develop a novel microemulsion me formulation to deliver phenylethanoid glycoside pg for use. Prajapati, shailendra kumar, ajit singh, ankush singh institute of pharmacy, bundelkhand university, jhansi, uttar pradesh, india 284128. The optimized microemulsion formulation b9 was subjected for various evaluation parameters such as, visual inspection, stability studies, ph, viscosity. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Introduction since from the past years, the oral drug delivery system has been taken to a new extent with the. All the collected samples added to 5 ml each of oils, surfactants. Microemulsions are prepared by the spontaneous emulsification method phase. Formulation and evaluation of nanoemulsion of amphotericin b harika k, subhashis debnath, m niranjan babu department of pharmaceutics, seven hills college of pharmacy, venkatramapuram, tirupathi 517561, andhra pradesh, india.
Preparation and invitro evaluation of self emulsifying drug. Vedha hari department of pharmaceutical technology, scbt, sastra university, thanjavur6401. Pdf formulation and evaluation of acyclovir microemulsions. The final product developed is a lyophilized amphotericin b, oil and surfactant blend for reconstitution in water to yield a microemulsion containing 5 mgml of the drug. A microemulsion forming systems is shown in figure 1. Microemulsions mes are clear, thermodynamically stable systems. The result showed that the microemulsion is a suitable carrier for catechin topical application. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Introduction the term microemulsion refers to a thermodynamically stable, isotropically clear dispersion of two immiscible liquids, such as. Formulation and characteristics of nicotinamideloaded microemulsions.
Optimization, development and evaluation of microemulsion for. A microemulsion preparation of nanoparticles of europium in. Preparation and evaluation of aceclofenac topical microemulsion. The pseudo ternary phase diagrams were developed for combinations of karanj oil as the oil phase, span20 as surfactant and as capryol 90 as cosurfactant using water titration method.
Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. In order to prepare the drug loaded microemulsions, a. Gels and microemulsions are classes of dosage forms that have emerged as promising drug delivery system for the delivery of various drugs. Preparation, characterization and evaluation of tenoxicam gels and microemulsion gels for topical drug delivery mai g elhennawy1, sally a abdel halim2, alia badawy2, mohammed a effat1 abstract. The drugloaded microemulsion formulation was stable for at least 3 months of storage at 25 c. Oil and the water phases can be combined with surfactant and a cosurfactant is then added at slow rate with gradual stirring untill the system is transparent. The preparation of microemulsion as a nanocarrier and its application for the delivery of chemical drugs has been the subject of growing studies. Among three types of microemulsion, namely oilinwater, waterinoil and bicontinuous, the first type is more useful in delivering oilsoluble drug molecules atashafrooz et al. The aim of study was to develop a microemulsion based tablets to increase the solubility. Optimization, development and evaluation of microemulsion. Formulation and characterization of microemulsion based. Microemulsion are having unique properties, namely, ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo.
Preparation, characterization and evaluation of tenoxicam. The microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. The present research work was conducted to formulate and evaluate anthralin microemulsion gel using karanj oil with an objective of improving solubility of the anthralin. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of.
Design and formulation of optimized microemulsions for dermal. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible. Pg as surfactantcosurfactant mixture scos in ratio of 15. Preparation and evaluation of microemulsionbased transdermal. Atorvastatin calcium is a hmgcoa inhibitor having an antihyperlipidemic effect. Original article formulation and evaluation of microemulsion. It belongs to the ii class of bcs classification hence formulating a microemulsion will increase its solubility dissolution and thus improves the oral bioavailability. Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Microemulsions for oral administration and their therapeutic. Pharmacodynamic evaluation also indicated lesser intensity of seizures in rats treated with optimized formulation in comparison to rats treated with oral carbamazepine microemulsion and nasal carbamazepine solution which suggested carbamazepine transnasal. Propofol possesses several favorable characteristics, including an antiemetic effect and rapid emergence from unconsciousness with minimal residual drowsiness. The method is significantly more straightforward than other extant methods. Self emulsifying drug delivery system sedds of valsartan using castor oil, tween80, peg600.
Preparation and evaluation of solid dispersion of candesartan. The drug is be dissolved in the lipophilic part of the microemulsion i. Jan 18, 2008 the present studies were designed to develop a formulation of amphotericin b in a lipidbased preparation as a microemulsion and to compare its toxicity with the commercial formulation fungizone. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. Preparation and evaluation of microemulsionbased transdermal delivery of total flavone of rhizoma arisaematis lina shen,1 yongtai zhang,1 qin wang,2 ling xu,2 nianping feng11department of pharmaceutical sciences, 2department of oncology, longhua hospital, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. Therefore, one should characterize microemulsion structures in detail for improving novel and effective techniques and applications. Development and evaluation of microemulsion based gel mbgs. Design and formulation of optimized microemulsions for. Preparation of microemulsion microemulsions were prepared at 27c by a titration method.
Microemulsions are easily prepared and require no energy contribution during preparation this is due to better thermodynamic stability. Preparation of nano and microemulsions using phase inversion and emulsion titration methods. A microemulsion preparation of nanoparticles of europium. Preparation of aceclofenac microemulsion aceclofenac was added to the mixtures of oil, surfactant, and cosurfactant with varying ratios as described in table 1, and then an appropriate amount of water was added to the mixture drop by drop with constant stirring on magnetic stirrer. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Formulation and evaluation of microemulsion based tablets of acyclovir for better patient compliance jatin dedakia, shivprasad h. Certain oils and surfactants were screened to select the most suitable ones for the preparation of microemulsions.
Formulation and evaluation of microemulsionbased hydrogel for. Preparation of microemulsions based gels after the microemulsion regions in the phase diagrams were identified, the microemulsion formulations were selected at different component ratios as described in table1. Solubility enhancement of nebivolol by micro emulsion technique. Formulation development, in vitro and in vivo evaluation of. Preparation of nicotinamide microemulsions and formulation. Formulation and evaluation of microemulsion based topical. For topical delivery semisolid preparation are widely accepted over solid and liquid dosage forms. Preparation and evaluation of fluconazole topical microemulsion article pdf available in journal of pharmacy research 23 january 2009 with 1,230 reads how we measure reads. The microemulsion is a system consisting of oil, water, surfactant, and cosurfactant that having a transparent or clear appearance with average droplet diameter of 6100 nm remington and allen, 2003.
Formulation and evaluation of microemulsion based delivery. Full text preparation and evaluation of microemulsion. For the preparation of emulgel, initially microemulsion was prepared. It was found that optimized microemulsion was stable and transparent with average globule size of 190 nm and diffusion flux of 75. Formulation and evaluation of microemulsion based luliconazole gel for topical delivery panchaxari mallappa dandagi, pratibha pandey, anand panchakshari gadad, vinayak shivamurthy mastiholimath department of pharmaceutics, kle college of pharmacy a constituent unit of kaher, nehru nagar, belagavi, karnataka, india. In order to develop an alternative formulation for the topical administration of np, microemulsions were evaluated as delivery vehicles. Evaluation of microemulsion based hydrogel globule size determination the average droplet size of samples was measured at 25c by malvern zeta sizer. Pdf preparation and evaluation of fluconazole topical. This may be considered as an extension of w insors classification form ing the fifth category. Different concentrations of sa were incorporated in an me base composed of isopropyl. Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Formulation, optimization and evaluation of atorvastatin. Formulation and characterization of microemulsion based gel.
Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. This article is from jundishapur journal of natural pharmaceutical products, volume 8. Abstract in the present work, levofloxacin based microemulsion was developed. Preparation and evaluation of cilnidipine microemulsion.
Valsartan is an angiotensin converting enzyme ace inhibitor with limited water solubility, which accounts for a low and. Optimization, development and evaluation of microemulsion for the release of combination of guaifenesin and phenylephrine s. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Formulation and penetration enhancement activity of sticks. The amount of surfactant and cosurfactant to be added and the percent of oil. They were used to solubilize drugs and to improve topical drug availability. Preparation and evaluation of microemulsion systems. The mechanism of drug release from microemulsionbased. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. Majumdar sptm, svkms nmims, shirpur, dhule 425 405, maharashtra, india. Microemulsion formulation design and evaluation for.
This invention is about preparation method of microemulsion based hydrogels containing the procedure methods which are. Salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. Particle size and zeta potential measurements ispersity index pdi of me. Formulation, optimization and evaluation of atorvastatin calcium loaded microemulsion. Mandal baroda college of pharmacy, vadodara, india. Preparation and invitro evaluation of self emulsifying drug delivery system of antihypertensive drug valsartan. Moreover, the microemulsion with and without catechin showed less irritant properties when compared with the standard irritant group. Evaluation of solid dispersions powder xray diffraction 6 to investigate the polymorphic transitions and the influence of carriers on these transformations during preparation of solid dispersion and the phase identification of a crystalline material lattice spacings were measured by xray diffraction. Formulation and evaluation of microemulsionsbased drug. A large number of oils and surfactants can be used for microemulsion. Preparation of microemulsions 203 tion of a stable microemulsion is more specific and thus greatly limited in variety. Microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and cosurfactant, can. Their small size leads to useful properties such as high surface area per unit volume, robust. Pdf preparation and evaluation of microemulsion containing.
The present research work describes a self emulsifying drug delivery system sedds of valsartan using castor oil, tween80, peg600. Labrafil m 1944 cs, labrafil m 2125 cs and capryol 90 were selected as oils while tween 80 was selected as a surfactant. Preparation and evaluation of transnasal microemulsion of. Development and evaluation of microemulsion based gel mbgs containing. Preparation and evaluation of novel microemulsion based hydrogels for dermal delivery of benzocaine. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant. The increased incidence of inflammatory diseases has. Preparation of drug loaded formulations the drug loaded microemulsion formulations were prepared by incorporating the drugs phenylephrine and guaifenesin in the previously prepared blank formulations. In order to prepare the drug loaded microemulsions, a stock solution containing econazole nitrate was prepared with the mixture of. Preparation and characterization of nicotinamideloaded microemulsions 35 3. Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. Pdf preparation and evaluation of novel microemulsion.
Preparation of drug loaded formulations the drug loaded microemulsion formulations were prepared by. The optimized microemulsion was composed of karanj oil 9%, span 20 41%, capryol 90 41% and water 9%. Preparation and evaluation of microemulsion systems containing. Pdf preparation and evaluation of microemulsion formulations of. Pdf formulation and evaluation of microemulsionbased. Doylea nanoemulsions are kinetically stable liquidinliquid dispersions with droplet sizes on the order of 100 nm.
The microemulsion was optimized on the basis of the transparency, drug release profile and particle size. Preparation of nano and microemulsions using phase. Characterization of microemulsions prepared using isopropyl. Preparation, characterization and invivo evaluation of. For other materials, the microemulsion contains all above plus one. This study was aimed to develop and evaluate emulgel formulation containing ketoprofen, as the market. Coarse emulsions can be stabilized by a wide variety of surfactants, application of high energy apparatus turbine mixers, sonicators, etc. Development and evaluation of microemulsion based gel. Preparation of drug solution the olz solution os meant for comparative evaluation of mmebased systems was prepared by dissolving olz 80 mg in 10 ml of propylene glycol resulting in a solution of 8 mgml kumar et al. This is an openaccess article distributed under the terms of the creative commons attributionnoncommercialshare alike 3. To select the best oil for preparation of micro emulsion formulation, saturated solubility.
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